创伤对微量元素硒代谢的影响

EFFECT OF TRAUMA ON SELENIUM METABOLISM

为了研究创伤机体硒代谢的改变情况,对创伤大鼠进行了硒代谢的平衡实验,并对临床手术病人进行了初步观察.结果表明,大鼠手术创伤后血清硒浓度和肝硒含量均明显低于对照组(P<0.05);伤后第1～3天内的硒代谢出现了负值.31例临床手术患者血清硒含量非常明显地低于术前水平(P<0.01).文章对术后低血硒的原因和平衡实验的结果进行了分析.建议应考虑对创伤患者和外科手术病人予以适量补硒.

In order to observe selenium metabolism of the wounded,Se balance was determined in 16 wounded rats and serum Se, Se excretion were studied before and after operation in 31 surgical patients.The results showed that the serum Se in rats decreased from 0.44 to 0.36μg/ml (P<0.05) after operation and liver Se was depressed until 7d (P<0.05),but urinary Se excretion increased by 24% during 1～3d after operation,Lower intake,decreased absorption and increased excretion led to nearly negative balances during 1～3d after trauma.Serum selenium of the patients decreased by 20% (P<0.O1) after operation.It is suggested that it is possibly beneficial for selenium supplementation in the wounded.