人胚胎肺内神经内分泌细胞电镜观察

ULTRASTRUCTURAL OBSERVATION OF NEUROENDOCRINE CELLS IN HUMAN FETAL LUNGS

用透射电镜对不同胎龄的人胚胎肺内神经内分泌细胞进行了发生和超微结构观察.肺内支气管上皮内未分化细胞,第八周开始向神经内分泌细胞转化,提示神经内分泌细胞对早期胚胎肺的发生、发育有特殊意义.神经内分泌细胞内致密核心小泡(DCV)及其它与内分泌活动有关的各种细胞器发达.能见到P_0细胞、P_1细胞、P_2细胞及P_3细胞等四种类型的神经内分泌细胞.P_0细胞的发生及分化程度表明它可能是一种前细胞,它可以进一步转化为P_1细胞、P_2细胞和P_3细胞.

With electron microscope,the histogenesis and ultrastructure of neruoendocrine cells (NE cell) in human fetal lungs were observed.At the 8th week,undifferentiated cells in the epithelium of intrapulmonary bronchi begin to transform into NE cells,which suggests that NE cells have special function for early histogenesis and tlevelopment of fetal lungs.In NE cells,DCV and other organelles for the secretory acton are flourishing.Four kinds of NE cells,Po cells,P_1 cells, P_2 cells and P_3 cells can be indentified.The characters of P_0 cells show that they are precursor cells and can change into P_1 cells,P_2 cells and P_3 cells.