摘要
目的:探讨终末期狼疮性肾炎(LN)的临床表现和治疗的关系。方法:分析1986年～1999年62例LN终末期肾脏病(ESRD)病人的临床活动性指标和死亡原因,分析比较LN与非LN透析病人的存活率。结果:本组LN病人发展至ESRD透析时,活动性指标的计分呈下降趋势,但机制未明;透析后3、6、10年存活率分别为81.25％、51.20％、32.12％,与非LN透析后的83.10％、54.37％、35.67％相比近似,而死亡原因以感染居多。结论:LN的ESRD期病人一般不需要抗SLE活动性的治疗;该期病人与非LN的ESRD期病人替代治疗的存活率之间,在统计学上无明显差异。
Objective: To investigate the relationship between the clinical manifestation and treatment of the end stage renal disease(ESRD) of lupus nephritis(LN). Methods :The clinical active index and the cause of death of 62 cases with ESRD of LN during 1986 to 1999 were studied . The survival rate of dialyzed patients were compared between LN and non - LN with ESRD. Results : There was a tendency of decrease of clinical active index in LN patients when dialysis was needed because of the development of ESRD . The pathophysiology of the quiescence remains unclear . The survival rate of LN patients 3 ,6 and 10 years after receiving dialysis were 81.25% , 51.20% and 32. 12% respectively , while were similar to those of non - LN ones (83.10 % , 54. 31 % and 35. 61 % respectively) . The death was mainly due to infection . Conclusion : The treatment against active SLE may be withdrawn in LN patients with ESRD . No statistic significance difference was found between LN and non - LN patients with ESRD with regard to the survival rate after renal replaced therapy .
出处
《中国中西医结合肾病杂志》
2000年第3期149-151,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
