银杏黄酮甙与抵克立得治疗原发性肾病综合征高凝状态的临床研究

Clinical Research on the Treatment of Hypercoagulable State in Primary Nephrotic Syndrome by Ginko flavonoid glycoside Tablet and Ticlid

目的:探讨活血化瘀中成药银杏黄酮甙片和抵克立得片(Ticlid)治疗原发性肾病综合征(PNS)高凝状态的临床疗效。方法:采用对比研究的方法,将64例PNS患者随机分成3组,3组均在同时采用标准疗程的泼尼松治疗的基础上。A组(20例)不另加药作为对照组;B组(22例)加银杏黄酮甙片口服治疗;C组(22例)加抵克立得片口服治疗。观察有关凝血及血液流变学指标的变化。结果:治疗后,B、C组血液流变学指标显著下降(P<0.01);凝血指标中FIB有显著下降(P<0.05),但PT、TT、APTT均无明显变化(P>0.05);A组各项指标无明显变化(P>0.05)。在治疗过程中,A组有2例(占2/20)发生肾静脉血栓形成,而B、C组则无此合并症者。结论:银杏黄酮甙片和抵克立得治疗PNS高凝状态疗效显著,能有效降低全血粘度,改善微循环,防止静脉血栓形成。

Objective: To investigate the clinical effect of Ginko flavonoid glycoside Tablet and Ticlid in treatment of hypercoagulable state of primary nephrotic syndrome(PNS). Methods: 64 cases of PNS were divided into three groups randomly, all are on the base of standard therapy of prednisone. Group A(20 cases), no other drugs as control group. Group B(22 cases) administered with Ginko flavonoid glycoside Tablet, Group C (22 cases) given Ticlid. then recorded the change of the index of coagulation and hemorrheology. Results; After the test, among group B and group C, the index of hemorrheology reduced signficantly(P<0.01), FIB decreased too (P<0.05), but PT. TT and APTT do not change very much( P > 0.05 ) . There is no obvious change of the above observed index in group A (P > 0. 05) . During the treatment, two cases of group A (2/20) were complicated by renal venous thrombosis, but no the same complication in group B and group C. Conclusion: Ginko flavonoid glycoside Tablet and Ticlid have obvious therapeatic effect in treatment of hypercoagulable state of PNS. They can decrease the blood viscosity, improve the microcirculation, prevent the venous thrombosis.