摘要
目的 探讨IL-6和TNF-α在膀胱癌的表达及相关性。方法 采用ELISA法对56例膀胱癌患者血清和尿液IL-6和TNF-α水平进行测定。结果 膀胱癌患者血清和尿液中IL-6和TNF-α水平与对照组有显著性差异(P<0.01),随肿瘤的分期升高而增加(P<0.01),而与膀胱癌病理分级无关(P>0.05)。同时,血清中IL-6和TNF-α水平呈正相关(P<0.01),而膀胱癌患者尿液中TNF-α水平与对照组无差异(P>0.05)。结论 IL-6和TNF-α在膀胱癌患者血清中的显著性表达、与临床分期的关系以及两者的正相关性,可作为判断膀胱肿瘤生物学活性的重要指标。
Objective To study expressions and correlation of IL-6 and TNF-a in bladder neoplasms. Methods Serum and urine levels of IL-6 and TNF-a were determined by means of enzyme-linked immunosorbent assay (ELISA) in 56 cases of bladder neoplasms. Results There was significant difference in serum and urine levels of IL-6 and TNF-a between the patients with bladder cancer and the controls(p<0. 01). And their levels were associated with tumor staging(p <0. 01), but not with tumor grading(p>0. 05). Moreover, IL-6 level in serum was found to be positively correlated with TNF-a level(p<0. 01). Whereas, no difference was found between the patients with bladder cancer and controls with regard to the urine level of TNF-α. Conclusions Serum levels of IL-6 and TNF-α were elevated greatly in patients with bladder cancer and were positively correlated with the clinical staging. It was suggested that IL-6 and TNF-α might serve as important parameters for judgment of biological behavior of bladder cancer.
