脑血疏通口服液对实验性脑出血大鼠脑水肿及脂质过氧化作用的影响

Effects of Naoxueshutong Oral Liquid On Cerebral Edema and Lipid Peroxidation in Rats with Experimental Cerebral Hemorrhage

目的 :探讨益气化瘀中药对出血性中风的疗效机理。方法 :建立实验性脑出血大鼠模型 ,观察脑血疏通口服液对脑水肿及脂质过氧化作用的影响。结果 :模型组脑系数、脑组织含水量较正常组第 3d均显著升高 ( P<0 .0 5或 0 .0 1 ) ,第 7d开始下降 ,但仍较正常组为高 ( P<0 .0 5) ,第 1 4d均与正常组相近 ( P>0 .0 5)。脑血疏通口服液大、小剂量组及脑血康组均可不同程度降低脑系数及脑组织含水量 ,以大剂量组为著。模型组第 3d MDA含量明显增高 ,SOD显著下降 ( P<0 .0 1 ) ,第 7d均接近正常组。用药各组均可不同程度降低MDA含量 ,提高 SOD活性 ( P<0 .0 1 ) ,且大、小剂量组 SOD活性高于脑血康组 ( P<0 .0 1 )。结论 :脑血疏通口服液具有改善脑水肿和抗脂质过氧化作用 ,可用于出血性中风的治疗。

Objective: To study mechanism of curative effects of Naoxueshutong oral liquid (NXST),the Chinese drugs for supplenmenting qi and resolving blood stasis. Methods: the experimental cerebral hemorrhage model had been erected,and the effects of NXST on cerebral edema and lipid peroxidation in Rats had been explored. Results: The model group's cerebral coefficients and quantities of containing water in cerebral tissue were higher than those of normal control group on the third day ( P <0 05 or 0.01),and it began to decrease on the seventh day,but it was higher than the normal group until the fourteenth day ( P <0 05). The NXST dose group,the low group and the Naoxuekang (NXK) group can all decrease the cerebral coefficients and quantities of containing water in cerebral tissue were higher. The high dose group showed most significant effect. The MDA content were significantly higher and the SOD activity were significantly lower ( P <0 01) in the model group. Every group can decrease MDA content and increase SOD activity different levels ( P <0 01),the SOD activity in higher dose group and low dose group were higher than NXK group. Conclusion: NXST,the Chinese drugs for supplenmenting qi and resolving blood stasis,showed markedly improving effect on hydrocephalus and lipid perexodation,thus,it has therapeutic effect in treating cerebral hemorrhage.