复合应激因素致“慢性疲劳”模型大鼠脾脏β-肾上腺素能受体变化的研究

Research on the Change of the Beta Adrenergic Receptor in the Animal Model of Chronic Fatigue

目的 :为了进一步探讨慢性疲劳综合征的发生机制以及中医肝脾功能在神经 -内分泌 -免疫网络调节中的作用。方法 :在应用过劳、情志刺激等复合应激因素机制“慢性疲劳”动物模型的基础上 ,检测了模型动物免疫器官脾脏组织中β-肾上腺素能受体的变化情况。结果 :“慢性疲劳”模型动物脾脏β-肾上腺素能受体数量较之对照组明显下降。结论 :中药复方“消疲怡神口服液”对该变化具有一定的调节作用。

To further approach to the pathological mechanism of chronic fatigue syndrome(CFS),the research based on establishing CFS animal model by multi stress factors,assayed the change of beta adrenergic receptor in the spleen of the animal model.The results showed CFS animal model appear the β adrenergic receptor concentration decreased and Xiaopiyishen have a certain regulating function to the changes.The study suggested the relationship between CFS and neuro endocrine immune net associate closely.