血管内皮生长因子在急性髓系白血病中的表达

Expression of Serum Vascular Endothelial Growth Factor Levels in Patients with Acute Myelogenous Leukemia

目的 研究急性髓系白血病 (AML)患者血清血管内皮生长因子 (VEGF)表达水平及其与预后的关系。方法 采用酶联免疫吸附法 (ELISA)对 4 5例初治、12例复发AML患者血清VEGF表达水平进行检测。结果 4 5例初治、12例复发AML患者的血清VEGF表达水平分别为 2 11.75± 10 8.33pg/mL和 2 37.17± 113.5 6pg/mL ,均明显高于正常对照组 (119.5 1± 4 1.6 0pg/mL ;P <0 .0 5 )。初治AML患者中VEGF高表达组 (>2 11.75pg/mL)完全缓解 (CR)率为 5 2 % ,低表达组 (<2 11.75pg/mL)CR率为 75 % ,两者比较差异显著 (P <0 .0 5 )。结论 血管内皮生长因子在刺激白血病细胞增殖、迁移中发挥重要作用。AML患者血清VEGF水平与预后具相关性。

Objective To investigate expression and prognostic significance of serum vascular endothelial growth factor(VEGF) levels in patients with acute myelogenous leukemia (AML).Methods Serum VEGF levels in 45 newly diagnosed?12 relapsed AML patients were determined by enzyme linked -immunosorbent assay(ELISA).Results Serum VEGF levels in newly diagnosed and relapsed AML patients were 211.75±108.33pg/mL and 237.17±113.56pg/mL respectively, obviously higher than the control group(P<0.05). Complete remission (CR) rates were 52% and 75% in newly diagnosed patients with VEGF levels above and below 211.75pg/mL, respectively(P<0.05).Conclusion VEGF plays a major role in the growth?proliferation and migration of hematopoietic malignancies cells. Serum VEGF levels have prognostic significance in patients with AML.