多发性骨髓瘤血液流变学的临床研究

Clinic Study on Blood Rheology of Multiple Myeloma

目的 探讨多发性骨髓瘤 (multiplemyeloma ,MM)患者血液流变学改变及血浆置换对多发性骨髓瘤患者高粘滞血症的疗效。方法 用全自动血液粘度快测仪检测全血粘度 (2 0 0s-1、30s-1、3s-1)、全血还原粘度、血浆粘度、红细胞聚集指数 ,用常规方法检测血沉、球蛋白 ,对 7例球蛋白 >35g/L患者行血浆置换。结果 多发性骨髓瘤患者全血粘度、全血还原粘度、血浆粘度、红细胞聚集指数 ,血沉、球蛋白显著增高 ,血浆置换能降低球蛋白、血粘度。结论 多发性骨髓瘤患者高球蛋白血症是导致高粘滞血症的基础。

Objective To explore the change of blood rheology of multiple myeloma and the effects of plasma exchange on blood hyperviscosity of multiple myeloma.Method 200s -1,30s -1,3s -1 whole blood viscosity,whole blood reduced viscosity,plasma viscosity and erythrocyte aggregation indexes were measured by full-automatic blood viscometer.Blood sedimentation and globulin were measured in usual ways.Seven patients,whose globulin were over 35g/L,received plasma exchange.Result Whole blood viscosity, whole blood reduced viscosity, plasma viscosity,erythrocyte aggregation indexes,blood sedimentation and globulin of multiple myeloma were elevated excellently.Plasma exchange reduced globulin and blood viscosity.Conclusion The hyperglobulinemia is the reason of high blood viscosity.