摘要
AIM: To evaluate the clinical value of plasma apolipoprotein A-I (Apo A-I) as a marker of fibrosis in children with chronic hepatitis B (CHB).METHODS: Liver biopsy specimens from 49 children with CHB were evaluated by using Knodell index. Plasma Apo A-I level was measured after 12-h fasting. Student's ttest, Spearman's correlation test and receptor-operating characteristic (ROC) curve were used for statistical evaluation.RESULTS: Mean Apo A-I level of the patients was not different from that of controls (P>0.05). Six (8.7%) children had fibrosis score of more than 2 (severe fibrosis). No difference in the level of mean plasma Apo A-I was found among children with and without severe fibrosis (P>0.05). No correlation between Apo A-I level and fibrosis scores was found (P>0.05). The area under the ROC curve was 0.407~0.146 (P>0.05).CONCLUSION: Severe fibrosis is not common in children with CHB and plasma Apo A-I level is not a reliable indicator of fibrosis.
AIM:To evaluate the clinical value of plasma apolipoprotein A-I(Apo A-I)as a marker of fibrosis in children with chronic hepatitis B(CHB). METHODS:Liver biopsy specimens from 49 children with CHB were evaluated by using Knodell index.Plasma Apo A-I level was measured after 12-h fasting.Student's ttest, Spearman's correlation test and receptor-operating characteristic(ROC)curve were used for statistical evaluation. RESULTS:Mean Apo A-I level of the patients was not different from that of controls(P>0.05).Six(8.7%)children had fibrosis score of more than 2(severe fibrosis).No difference in the level of mean plasma Apo A-I was found among children with and without severe fibrosis(P>0.05).No correlation between Apo A-I level and fibrosis scores was found(P>0.05). The area under the ROC curve was 0.407±0.146 (P>0.05). CONCLUSION:Severe fibrosis is not common in children with CHB and plasma Apo A-I level is not a reliable indicator of fibrosis.
