肝硬化血清甲状腺素与层粘蛋白水平的相关性研究

Relationship Studies between Serum Thyroxine and Laminin in Patients with Liver Cirrhosis

目的 :探讨肝硬化血清甲状腺素水平与肝硬化病变程度及血清层粘蛋白浓度的相关性。方法 :用电化学发光法和放射免疫法分别测定 72例不同程度肝硬化患者血清甲状腺素含量与层粘蛋白水平。结果 :随着临床肝硬化程度的加重 ,层粘蛋白 (LN)含量逐渐增高 ,而三碘甲状腺原氨酸 (T3 )、游离三碘甲状腺原氨酸 (FT3 )随层粘蛋白的增高而下降 ,且T3 、FT3 与LN含量均呈显著负相关 (r =- 0 5 4 3和 - 0 5 0 6 ,P <0 0 5 ) ,而甲状腺素 (T4)、游离甲状腺素 (FT4)可正常或下降。但在肝功能严重衰弱时 ,则多呈低下。结论 :肝硬化时 ,T3 、FT3 与LN呈显著负相关 ,联合检测LN与T3 、FT3 及T4。

Objective: To explore the interrelation between serum thyroxine and laminin in patients with liver cirrhosis. Methods: The concentrations of serum laminin and thyroxine were determined by electrochemi luminescence immunoassay and radioimmunoassy in 72 patients with different degree of liver cirrhosis. Results:It showed that the serum LN (laminin) increased gradually with the degree of clinical liver cirrhosis deteriorated .But they were most likely in a low concentration when liver function deteriorated seriously. Conclusion: It is suggested that there is a significantly negative relation between T_3,FT_3 and LN.Measuring simultaneously the concentration of LN,T_3,FT_3,T_4 and FT_4 has utilizable and reliable clinical value in predicting the degrees and prognosis of liver cirrhosis.