慢性丙型肝炎患者外周血T淋巴细胞亚群与HCV-RNA的关系

Relationship between Peripheral T - lymphocyte Subset and HCV-RNA in Chronic Hepatitis-C

对48例血清HCV-RNA阳性和35例HCV-RNA阴性的慢性丙型肝炎(慢丙肝)患者外周血T淋巴细胞亚群进行观察,并与20例正常人对照。结果显示:两组慢丙肝患者与正常人比较CD_3、CD_4、CD_4/CD_8均明显降低,CD_8明显升高;而两组慢丙肝患者间无明显差异。认为HCV感染诱导的这种细胞免疫变化并不能清除HCV。

Peripheral T-lymphocyte subsets of 48 HCV-RNA seropositive and 35 HCV-RNA seronegative chronic hepatitis -C patients were investigated arid 20 normal subjects were kept as control. Results showed that both chronic hepatitis-C groups compared with the control, CD3, CD4, CD4/CD8 decreased and CDsincreased significantly but there is no significant differences between the two patient-groups. It indicates that HCV cannot be deleted by HCV -induced cellular immunologic reaction