侵袭性垂体腺瘤的生物学特性研究──临床、病理、细胞动力学研究

The biological characteristics of invasive pituitary adenomas

目的：深入了解侵袭性垂体腺瘤的生物学特性，以提高其诊断、治疗水平。万法：对54例病人（非侵袭性垂体腺瘤31例，侵袭性垂体腺瘤23例）的临床、病理、细胞动力学三方面资料作差异显著性检验及相关性分析。结果：在临床表现方面，两组病人在病程，肿瘤大小，肿瘤组织坏死、卒中、囊变发生率，手术全切除率，术后复发率方面有显著差异（P＜0．05）。病理学方面，两组在微血管定量方面有显著差异（P＜0．05）。细胞动力学的研究显示：侵袭性垂体腺癌的细胞增殖速率显著大于非侵袭性腺瘤（P＜0．01）。结论：侵袭性垂体腺瘤临床进展快，多为大腺瘤，肿瘤组织坏死、囊变、卒中发生率高，手术全切除率低，术后易复发，肿瘤血供较为丰富，肿瘤细胞增殖较快。

Object To find out the biological charaterishcs of invasive pituitary adenomas. Method 54 patients (23 invasive pituitary adenomas, 31non - vasivetumors) were investigated clinically, pathologically and cell - kinetically. Result Significant clinical dtherence existed between two poups in interval time between symptom appearance and admission, tumor size, the incidence of apoplexy and cystic components, complete surgical removal and postoperative recurrence. In patholog ical findings, it was found that invasive adenomas had a higher micro -vascular density. And research on cell kinetics found that invasive pituitary adenoma had a higher prolifezating rate. Conclusion Invasive pituiteq adenomas are always large one, have a fast clinical progress, a high incidence of apoplexy, a low rate of complete tumor removal and a high rae of postoperative recurrence. Tumor blood supply is more sufficient and tumor cell proliferaing rate is higher.