蒿甲醚肌注对索马里恶性疟的疗效观察

The therapeutic efficacy of artemether injected intramuscularly on patients with falciparum malaria in Somalia

1988～1989年在东非索马里南部疟区,观察用蒿甲醚、氯喹治疗恶性疟的效果。蒿甲醚油剂肌肉注射(成人总量600mg,第1d 200mg、第2～5d各100mg;儿童药量按年龄逆减)治疗索马里成人15例、儿童22例和中国成人13例。氯喹片剂口服(成人总量1500mg基质,第1、2d各600mg,第3d 300mg)治疗索马里成人14例。以退热、原虫转阴时间和28d治愈率评价药效。结果表明,对索马里成人恶性疟病例的疗效,蒿甲醚优于氯喹。2例抗氯喹恶性疟用蒿甲醚治愈。蒿甲醚对有免疫力的索马里成人、儿童和无免疫力的中国成人恶性疟病例的疗效相近。本研究结果为蒿甲醚用于非洲当地及外来人群恶性疟疾病人的治疗提供了临床药效资料。

Fifty patients (Somali adults 15 cases and children 22 cases, Chinese adults 13cases) were treated with artemether oil preparation injected intramuscularly (total dose for adult600mg i.e. 200mg on D_0 and 100mg on D_(1-4), children's dose decreased with age). Fourteen pa-tients (Somali adults) were treated with chloroquine diphosphate tablet per os (total dose 1500mgbasee i.e. 600mg, on D_1 and 300mg on D_2). The results showed that the therapeutic efficacy ofartemether was superior to that of the chloroquine, two patients resistant to chloroquine werecured by artemether. The efficacy of artemether was approximatety the same on patients with orwithout immunity. This study indicated that artemether was suitable to treat patients withfalciparum malaria either sensitive or resistant to chloroquine in Somalia, Africa.