大鼠吸入氧化钚后肺内α粒子自显影径迹定量分析

Quantitative morphological analysis of the autoradiographic traces of alpha particles emitted from ^(239)Pu-deposition in rat lung after inhalation of ^(239)PuO_2 aerosol

应用四川大学计算机科学研制的MIAS-300图像分析仪,对大鼠吸入氧化钚气溶胶(肺初始沉积量为3.4±0.4kBq)后0.5～90d不同时间,肺沉积钚α粒子放射性自显影径迹集落的形态进行了定量分析。分析的参数主要有:径迹集落的面积、周长、等效直径、数密度、体积密度和形状因子等。结果说明,上述参数除形状因子外,均随着吸入后时间的增加而降低;用指数或幂函数模型进行曲线拟合,具有较好的函数依赖关系;对体积密度与吸入后0～90d时间作定积分计算,结果表明,在上述时间范围内,每天平均有1.54±0.06%的肺组织受到钚α射线的直接照射。

A quantitative morphological analysis of the autoradiographic traces of alpha par-ticles emitted from ^(239)Pu-deposition in rat lung after inhalation of ^(239)PuO_2 aerosol was conductedby means of MIAS-300 image analyzer. Six parameters were measured: the areas, the perimeter,the equivalent circle diameters, the numerical density, the volume density and the form factor ofautoradiographic traces. It was found that all parameters, except the form factor, decreased grad-ually with time after the inhalation of ^(239)PuO_2 aerosol.