胃肠道肿瘤癌基因、抑癌基因变化研究进展

Advance in oncogene and tumor suppressor gene alteration study in gastrointestinal cancer

通过大量的肿瘤分子生物学研究,一些规律性的基因变化已在胃肠道肿瘤中被发现。涉及结直肠肿瘤发生发展的主要基因事件包括三个抑癌基因位点(p53,Dcc,apc/mcc)异常和一个原癌基因(ras)点突变激活。p53突变,ras癌基因突变,两个生长因子家族的癌基因(EGFR,c-erbB-2)扩增和超表达,癌蛋白P21的异常表达,某些染色体位点的缺失,则与胃癌的演进密切相关。

Some regular gene alterations have been found in gastrointestinal cancer and othertumors by molecular biological study. The major gene events involved in colorectal carcinoma in-cluded abnormal changes of p53, Dcc, apc/ mcc and ras mutation, p53 mutation, ras mutation,amplification and over-expression of oncogenes EGFR and c-erbB-2 over-expression of P21protein and loss of some chromosome loci are closely correlated with the development of gastriccancer.