应用转基因小鼠研究癌基因在整体水平的表达与调控

In vivo expression and regulation of oncogenes assessed by transgenic mice

概述了应用转基因小鼠研究癌基因表达与调控的方法及癌基因与调控序列融合的三种基本方式,以及近年来该领域的主要研究进展和发展趋势。

The authors described ways to evaluate the expression and regulation of oncogenes by transgenic mice and gave three forms of ligation of onco-genes to the regulatory sequences. Recent ad- vances in this field are reviewed and the potential research targets are pointed out.