摘要
目的了解引起胆道感染的主要病源菌及其对药物的耐药性。方法对287例胆道病患者在手术中无菌引流胆汁进行细菌培养及药敏测试,其中有14份胆汁同时做了厌氧培养。结果287份胆汁中有168份标本培养出细菌;阳性检出率58.5%。共培养出细菌184株,其中革兰氏阴性杆菌112株(占60.8%);革兰氏阳性球菌68株(占36.9%);厌氧菌3株(占1.6%);真菌1株(占0.5%)。用K-B纸片扩散法做药敏分析,结果显示:大肠埃希菌和克雷伯菌对多种类药物都有不同程度的敏感性。除氨苄西林、磺胺耐药率67.5%-58.1%外,其余类药物耐药率均小于31%。而铜绿假单胞菌、其它非发酵菌、肠杆菌属及粪肠球菌和葡萄球菌则出现多重交叉耐药。对青霉素类、磺胺耐药率在80%,头孢类耐药率大于70%。结论胆道感染病原菌主要为大肠埃希氏菌、粪肠球菌、克雷伯菌、肠杆菌及其它链球菌。对三代头孢、哌拉西林、阿米卡星、庆大霉素及亚胺培南有较高敏感性。
Objective: To find out the main pathogenic bacteria and their resistant strain in cholangitis.Methods: 287 cases′ bile were collected, germiculture and antibiotic susceptibility test were carried out, 14 cases of those had been anaerobic cultivated at one time. Results: 168 cases had found out bacteria in 287 cases, positive rate was 58.5% and 184 kinds bacteria were found, G- 112(60.8%), G+ 68(36.9%); antibiotic 3(1.6%),epiphyte1 (0.5%). The result of antibiotic susceptibility with K-B method shows: Escherichia coli and klebsiella had susceptibility to many medicines to some degree. Beside ampicillin′s and sulfanilamide′s resistant strain rate was 67.5%~58.1%, all others′ were less than 31%. Mucor racemosus, other non-zymogen, intestines bacilli and group entercoccus, staphylococcus appeared multi-acrossed medicine resistant. 80% of those bacteria resistanted picilline and sulfanilamide, 70% resistanted cephalosporin. Conclusion: the main pathogenic bacteria in cholangitis are Escherichia coli, group entercoccus, klebsiella, intestines bacilli and other streptococcus and have high susceptibility to cefobid Fortum, Piperacillin, Amikin, Gentamycin and Tienam.
出处
《中国医学工程》
2004年第5期94-96,共3页
China Medical Engineering