肝肾疾病患者血清转铁蛋白和铜蓝蛋白含量的分析

The Measurement of Serum Transferrin and Ceruloplasmin in Patients with the Liver and Renal Diseases

对肝肾疾病进行转铰蛋白(Transferren简称TF)和铜蓝蛋白(Ceruloplasmin简称CP)测定,结果表明:各组肝炎病人的TF均显著低于正常组,且谷丙转氨酶异常和HBsAg阳性者TF含量明显低于正常者,TF可作为判断肝病预后的一个指标。肾炎病人的TF也比正常人低,CP含量各组不一,肝癌患者的CP(52.44±8.73mg％)显著高于正常人(46.75±7.92mg％),乙型肝炎病人和正常组间未见差异.肝豆状核变性患者CP非常显著低于正常人,故检测CP有助于鉴别肝硬化和肝癌,同时对临床诊断肝豆状桉变性提供一项可靠的客观指标.

In this report, we have determined serum transferrin (TF) and ceruloplasmin (CP) in patients with liver and renal diseases. Results indicate that TF in all hepatitis groups are significantly lower than that in the nor- mal group. The TF level in patients with abnormal GPT and positive HBsAg are significantly lower than that in normal persons. Therefore, the TF level may be referred to as an index for the hepatitis prognosis. The TF level in nephropathy patients are also lower than that in normal persons. Contents of CP in each group are not similar, for example in patients with hepatic carcinous (52.44±8.73mg％) are significantly higher than that in the normal group (46.75±7.92mg％), but there is no significant difference between hepatic B and normal group. Contents of CP in hepatolenticular degeneration are significantly lower than that in normal group (P< 0.001). Therefore, measurement of CP which provides an available objective index is helpful to distingulsh the hepatocirrhosis from liver carcinosis and hepatolenticular degeneration.