摘要
通过分析13种生物120余种蛋白质的分子进化,首次揭示:配基-受体、蛋白酶-酶抑制剂、亚基-亚基等相互作用蛋白质间在纵向进化(物种间)、横向进化(不同功能蛋白质间)中均存在协同进化的规律.此结果表明,相互作用蛋白质其分子进化普遍为非随机过程,由于其相互作用为功能发挥所必需,因而彼此间以典型的达尔文选择方式进化.本文结果既弥补了中性理论中分子进化与功能方式无关的不足,亦指出达尔文选择适用于分子进化。
The molecular evolution of 120 kinds of proteins derived from 13 species has been analysed. The results
demonstrated a principle that interacting proteins such as ligand-receptor, proteinase-proteinase inhibitor sub-
unit-subunit, evolved together in a concerted fashion either in vertical evolution(among various species) or in
horizontal evolution(among distinct proteins). This principle argued against the neutral theory of molecular
evolution established by Motoo Kimura, and suggested that Darwinian selection might play an important role
in molecular evolution of interacting proteins.
出处
《科技通报》
1993年第6期353-358,共6页
Bulletin of Science and Technology
基金
国家自然科学基金
863部分资助
关键词
蛋白
达尔文选择
分子进化
interacting protein
concerted evolution
neutral evolutionism
Darwinian selection
