胃癌化疗的卫生经济学评价

目的 探讨不同化疗方案对晚期胃癌所产生的经济效果比。方法 根据文献报道的 2种常用晚期胃癌化疗方案 :5 -氟尿嘧啶 (5 -FU) /阿霉素(ADM) /甲氨蝶呤 (MTX) (FAMTX方案 )和表阿霉素(EPI) /顺铂 (DDP) /5 -FU (ECF方案 ) ,运用药物经济学成本效果分析方法进行比较。结果 2种方案治疗晚期胃癌的成本分别为 5 115 84元和 4 5 80 0 0元 ,化疗后中位生存期根据文献报道分别为 6 1个月和 8 7个月。每获得 1个单位效果 ,2种方案所需花费的成本依次为838 6 6元和 5 2 6 4 4元。结论 ECF方案成本 -效果比低 ,与FAMTX方案比较 ,ECF方案疗效更好 ,费用更低。

Objective To discuss the economic effect of different chemotherapeutic regiments for advanced gastric cancer.Methods According to the literatures,we selected two of the most common used chemotherapeutic regiments including FATMTX and ECF.Data was evaluated by using the pharmacoeconomic cost-effectiveness analysis.Results The costs of the two regiments were 5115.84 and 4 580.00 yuan respectively.The median survival of the tow regiments were 6.1 months and 8.7 months.838.66 yuan and 526.44 yuan per effective rate were needed respectively.Conclusion Compared to FAMTX regiment,ECF had the lower cost-effective ratio.ECF had the better curative effect and the lower cost.