活血通腑方对大鼠术后血FIB、FDP水平的影响

Square Impact on Blood FIB,FDP Level on Post-operative Rats that Invigorate Blood Circulation and Remove Heat by Catharsis

目的 观察活血通腑方对实验性腹腔粘连大鼠血FIB及FDP含量的影响 ,探讨其防治腹腔粘连的机制。方法 将 12 0只SD雄性大鼠 (清洁级 )随机分为实验组 (活血通腑方组 )、对照组 (四磨汤口服液组 )、模型组、假手术组 4组 ,每组 30只。分别进行胃内药物灌注 ,测定术后 1、 3、 5、 7、 2 1d时血FIB、FDP含量 ,观察腹腔粘连情况并进行比较。结果 活血通腑方组术后 5、 7、 2 1d时血FIB含量降低 (P <0 0 1) ,术后 3、 5、 7、 2 1d时血FDP含量升高 (P <0 0 5 ) ;4组大鼠腹腔粘连程度评定 ,各分值间差别有显著性意义 (P <0 0 1)。结论 活血通腑方能使大鼠术后血FIB降低、FDP升高 ,从而防治腹腔粘连。

Objective To observe the influence of invigorating blood circulation and removing heat by catharsis it to the content of the experimental abdominal cavity adhesion big rat′s blood FIB and FDP,probe into it and prevent and cure abdominal cavity′s adhesion mechanism.Methods 120 model S D male rats(clean grade),divided into experiment group (it is removed heat by catharsis square group to invigorate blood circulation ),contrast group (four rub soup oral liquid group ),model group,false operation group four groups at random,30 rats of every group.The medicine is poured into the stomach separately,determine blood FIB,FDP content in 1,3,5,7,21 days,observe abdominal cavity′s adhesion change to compare.Results The content of blood FIB is reduced in 5,7,21 days after group′s skill of the experiment (P<0.01);3,5,7,21 days (P<0.01 ) after the skill,the content of blood FDP is rising (P<0.05 ); Relatively there is a remarkable difference (P<0.01 ) in four groups of abdominal cavity′s adhesion degree.Conclusion It can make blood FIB reducing and FDP rising after the rats′ skill,thus preventing and curing abdominal cavity′s adhesion.