正电子发射体层显像在头颈部肿大淋巴结定性中的临床价值

The usefulness of FDG-PET in patients with cervical lymphadenopathy

目的 探讨正电子发射体层显像 (PET)检查对于头颈部肿大淋巴结定性的应用价值。方法 对 1999年 3月～ 2 0 0 1年 10月 2 7例伴头颈部淋巴结肿大的患者行全身18氟 脱氧葡萄糖(FDG) PET检查 ,测取相应淋巴结的最大标准摄取值 (SUVmax)、平均标准摄取值 (SUVmean)和正常颈部组织的SUV(SUVneck)。所有恶性淋巴结全部得到病理确诊。结果 2 1例恶性肿瘤淋巴结肿大患者中 ,2 6个肿大淋巴结对FDG的摄取能力明显高于相应的正常颈部组织 (SUVmax ,SUVmean和SUVneck分别为 4 6 2± 2 31,3 4 5± 2 74和 0 5 5± 0 0 8,P <0 0 0 1)。其余 6例 9个良性肿大淋巴结未见显影。PET对头颈部淋巴结肿大定性诊断准确率高于颈部超声与CT、MR检查 (P <0 0 0 1)。结论 对于头颈部淋巴结肿大的患者 。

Objective To assess the usefulness of 2-(fluorine-18) fluoro-2-deoxy-D-glucose(FDG) positron emission tomography(PET)in patients with cervical lymphadenopathy.Methods From March 1999 to October 2001, 27 patients with cervical lymphadenopathy were imaged with FDG-PET.Maximum and mean standard uptake value(SUVmax and SUVmean) of lymphadenopathy and SUV of normal cervical tissue(SUVneck) were measured. All 21 patients with malignant lymphadenopathy got pathologically confirmed. Results All 26 malignant lymph nodes in 21 patients could be detected by FDG-PET.FDG uptake of these nodes was higher than that of cervical tissue (SUVmax,SUVmean and SUVneck were 4 62±2 31,3 45±2 74 and 0 55±0 08,respectively P <0 001).Other 9 benign lymph nodes in 6 patients couldn′t be detected by FDG-PET.The accuracy of PET in 21 patients with malignant lymphadenopathy, was higher than those of routine examinations such as ultrasonography plus CT or MR( P <0.001). Conclusions FDG-PET allows effective diagnosis of patients with cervical lymphadenopathy and can contribute substantially to patient care.