病理性瘢痕微量元素的初步研究

A primary study on the changes of trace elements in pathologic scars

目的:探讨病理性瘢痕微量元素含量的变化规律。方法:应用三电极直流等离子体-原子发射光电直读光谱仪检测:①瘢痕疙瘩、增生性瘢痕、扁平瘢痕、正常皮肤组织的Zn、Cu、Fe、Mn、Se5种微量元素含量;②瘢痕疙瘩和增生性瘢痕周围皮肤5种微量元素含量;③瘢痕疙瘩和增生性瘢痕中央部和边缘部组织5种微量元素含量。结果:瘢痕疙瘩和增生性瘢痕组织5种微量元素含量较扁平瘢痕和正常皮肤均减少,且较自身正常皮肤均显著性下降,而瘢痕疙瘩与增生性瘢痕间、扁平瘢痕与正常皮肤间、瘢痕疙瘩和增生性瘢痕患者自身皮肤与正常皮肤间差异无显著性意义;瘢痕疙瘩内部微量元素含量存在差异,其中央部5种微量元素含量较边缘部均增高,差异具有显著性意义,而增生性瘢痕中央部和边缘部差异无显著性意义。结论:瘢痕疙瘩和增生性瘢痕组织中微量元素变化与瘢痕的病理、生理改变有着密切的关系。

Objective:To study the changes of trace elements in pathologic scars.Method:DCP-AES was used to determine the contents of Zn、Cu、Fe、Mn、Se in:①Keloids、hypertrophic scars、flat scars and normal skins;②Skins of keloid patients、skins of hypertrophic scar patients;③The central and marginal portion of keloids and hypertrophic scars.Result:There were significant statistical decrease in contents of Zn、Cu、Fe、Mn、Se in keloids and hypertrophic scars in comparison with flat scars and normal skins,but no significant statistical changes in contents of Zn、Cu、Fe、Mn、Se in keloids and flat scars in comparison with hypertrophic scars and normal skins; There were no difference between the contents of Zn、Cu、Fe、Mn、Se in skins of keliod patients、skins of hypertrophic scar patients and normal skins; The contents of Zn、Cu、Fe、Mn、Se in keloids and hypertrophic scars were significantly lower than those in skins of the same patients;The contents of Zn、Cu、Fe、Mn、Se in central portion of keloids were higher than those in marginal portion,while the contents of Zn、Cu、Fe、Mn、Se in central portion of hypertrophic scars were same as those in marginal portion.Conclusion:The changes of trace elements in keloids and hypertrophic scars may correlate with excessive proliferation of pathologic scars.