2[2]Day CP,James OFW.Steatohepatitis:a tale of two this?[J].Gastroen-terology,1998,114:842.
3[3]Marchesini G,Brizi M,Bianchi G,et al.metformin in non-alcoholic steatohepatitis[J].The Lancet,2001,358:893.
4[4]Duseja A,Murlidharan R,Bhansali A,et al.Assessment of insulin re-sistance and effect of metformin in nonalcoholic steatohepatitis-a pre-liminary report[J].Indian J Gastroenterol,2004,23:12.
5[5]Neuschwander-Tetri BA,Brunt EM,Wehmeier KR.et al.Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone[J].Hepatology,2003,38(4):1008.
6[6]Promrat K,Lutchman G,Uwaifo GI,et al.A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis[J].Hepatology,2004,39(1):188.
7[7]Hasegawa T,Yoneda M,Nakamura K,et al.Plasma transforming growth factor-beta level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis[J].Aliment Pharmacol Ther,2001,15:1667.
8[8]Pietro Vajro,Claudia Mandato,Adriana Franzese,et al.Vitamin E treat-ment in Pediatric Obesity-Related Liver Disease : A Randomized Study [J].Journal of Pediatric Gastroenterology and Nutrition,2004,38,48.
9[9]Miglio F,Rovati LC,santoro A,et al.Efficacy and safety of oral betaine glucuronate in non-alcoholic steatohepatitis[J].Arzneimittel Forschung,2000,50:722.
10[10]Abdelmalek MF,Angulo P,Jorgensen RA,et al.Betaine,a promising new agent for patients with nonalcoholic steatohepatitis:results of a pilot study[J].Am J Gastroenterol,2001,96(9):2711.
7Mazzella G;Nicola R;Francesco A.Ursodeoxycholic acid administration in patients with cholestasis of pregnancy:effects on primary bile acids in babies and mothers[J],2001(03).
8Rodrigues CM;Ma X;Linehan-Stieers C.Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation[J],1999(09).
9Rodrigues CM;Fan G;Wong PY.Ursodeoxycholic acid may inhibit deoxycholic acidinduced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production[J],1998(03).
10Beuers U;Bilzer M;Chittattu A.Tauroursodeoxycholic acid inserts the apical conjugate export pump Mrp2 into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic ratliver[J],2001(05).