2型糖尿病表型与中医体质分类关系的研究

Studies on the relationship pheontype and constitution classification of traditional Chinese medicine in type 2 diabetes

目的:从生理和生化角度,探讨2型糖尿病患者不同表型与中医体质分类的相关性。方法:采用中医体质标准进行分类,并做空腹血糖、体重指数、心电图和生化等指标测定。结果:阴虚质、痰湿质和血瘀质分别占2型糖尿病的38.6%、46.3%、15.1%;血瘀质和阴虚质的空腹血糖、血脂均较痰湿质高,血肌酐水平血瘀质组最高,心电图的异常率血瘀质明显高于阴虚质和痰湿质组。结论:在2型糖尿病患者中痰湿质和阴虚质是两大基本类型,痰湿质患者多属于肥胖型,血瘀质预后可能要比其他体质的患者差。

Objective:To investigate the relationship between different phenotype and constitution classification of traditional chinese medicine in type 2 diabetes from the viewpoint of physiology and biochemistry.Methods:The constitution classification was performed according to the sorting standard of traditional chinese medicine.The fasting blood sugar(FBS),body weight index(BWI),electrocarodiogram(ECG),biochemistry indices and so on were measured respectively.Results:The proportion of yinxu,tanshi and xueyu constitution accounted for 38.6%,46.3%and 15.1%of the type 2 diabetes respectively.The levels of FBS and blood-lipid in xueyu and yinxu constitution were higher than those in tanshi constitution,the level of blood creatinine in xueyu constitution was the highest.The abnormal rate of electrocardiogram(ECG) in xueyu constitution was higher than that in yinxu and tanshi constitution.Conclusion:Tanshi and yinxu constitution are two essential types in patients with type 2 diabetes,the tanshi constitution mostly belong to obese type.The prognosis of xueyu constitution may be not good compared with that of other constitution types.