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活性依赖的听觉中枢可塑性分子机制 被引量：1

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摘要 外周活性依赖的听觉可塑性分子机制涉及兴奋性突触后膜N 甲基 D 天冬氨酸受体 (N methyl D aspartatereceptors,NMDARs)激活所诱导的a amino 3 hydroxy 5 methylisoxazole 4 propri onicacid (AMPA)受体 ,NMDARs和有丝分裂原活化的蛋白激酶 (mitogen activateproteinkinases,MAPK)参与的基因转录调节及突触局部选择性mRNAs翻译调节 ,本文综述了近年来有关听觉传入活性改变引起听觉中枢可塑性的基因转录产物表达变化和中枢神经系统突触局部mRNAs选择翻译及这两种调节的可能机制。
作者 阮清伟 王正敏
机构地区 复旦大学附属眼耳鼻喉科医院耳鼻咽喉科
出处 《国外医学（耳鼻咽喉科学分册）》 2004年第6期336-340,共5页 Foreign Medical Sciences(Section of Otolray Ngology Foreign Medical)
关键词 活性依赖 听觉中枢 可塑性分子机制 有丝分裂原活化的蛋白激酶
分类号 R764 [医药卫生—耳鼻咽喉科]
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参考文献24

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同被引文献6

  • 1Paxinos G,Watson C.大鼠脑立体定位图谱[M].北京:人民卫生出版社,2005:25.
  • 2Guzowski J F, Lyford G L, Stevenson G D, et al. Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory [J ]. Neurosci, 2000, 20:3993-4001.
  • 3Panford-Walsh R. Midazolarn Reverses Salicylate-Induced Changes in Brain-Derived Neurotrophic Factor and Arg3.1 Expression:Implications for Tinnitus Perception and Auditory Plasticity [J ]. Molecular Pharmacology, 2008, 74: 595-604.
  • 4Tzingounis A V, Nicoll R A. Arc/Arg3.1 : linking gene expression to synaptic plasticity and memory [ J ]. Neuron, 2006, 52:403-407.
  • 5Mahlke C, Wallhausser-Franke E. Evidence for tinnitusrelated plasticity in the auditory and limbic system, demonstrated by arg3.1 and c-fos immunocytochemistry [ J ]. Hearing Research, 2004, 195 : 17-34.
  • 6李明,杨光,关颖,马兆鑫.耳鸣动物行为学模型的制作[J].中国中西医结合耳鼻咽喉科杂志,2003,11(3):108-111. 被引量：13

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国外医学（耳鼻咽喉科学分册）
2004年 第6期

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