氟西汀对乳腺癌抑郁症患者生活质量的疗效研究

Effect of Fluoxetine on Quality of Life in Breast Cancer Patients with Depressive Symptoms

目的 :探讨氟西汀对乳腺癌患者抑郁、焦虑症状的疗效及安全性 ,并全面评价患者用药前后的生活质量。方法 :对 6 3例乳腺癌抑郁症患者进行 8周的氟西汀治疗 ,采用汉密尔顿抑郁量表 (HAMD)、汉密尔顿焦虑量表 (HA MA)、副反应量表 (TESS)和相关实验室检查评价氟西汀对乳腺癌抑郁症患者抑郁、焦虑的疗效以及安全性 ,采用世界卫生组织生存质量评定量表 (WHOQOL)评价患者用药前后的生活质量。结果 :治疗后患者焦虑、抑郁情绪比入组时明显降低 (P <0 .0 1) ,有效率分别为 6 5 %和 5 2 % ;患者用药期间未出现明显药物副反应 ;患者生活质量中的生理、心理、独立性三个领域有明显改善。结论 :本研究结果显示氟西汀能明显改善乳腺癌患者的抑郁、焦虑症状 ,起效时间为 2～ 4周 ;治疗期间副反应较少 ;应用氟西汀治疗患者抑郁症状的同时能明显提高患者的生活质量。

Objective: To study the effect and reliability of fluoxetine on depression and anxiety symptoms in breast cancer patient, and to assess the overall quality of life before and after treatment. Methods:We treated 63 breast cancer patients with depression by use of Fluxetine for 8 weeks, at the same time, evaluated their emotion state, change of quality of life and the adverse effect with HAMD、HAMA、TESS and laboratory tests. Results: After 8 weeks, patients' scores of anxiety and depression decreased significantly from the baseline( P <0.01), effective rates were 65% and 52% respectively.Three domains of quality of life (physiology, psychology and independence) became much better than those of baseline( P <0.05). Conclusion:This study shows that fluoxetine can reduce the depression and anxiety symptoms in breast cancer patients, and the react time is 2 to 4 weeks. Fluoxetine with the treatment of depression and enxiety can improve the patients' quality of life.