凉润通络中药对糖尿病胃轻瘫患者血清胃泌素及体表胃电图的影响

Effects of Chinese Herbs for Cool moistening and Freeing Collaterals on Serum Gastrin and Surface Electro gastrogram in Patients of Diabetes Mellitus with Gastroparesis

目的探讨凉润通络中药对2型糖尿病胃轻瘫(DGP)患者胃动力障碍的影响。方法选择DGP患者53例,分别用凉润通络中药(中药组28例)和西沙比利(西药组25例)治疗4周,并观察两组治疗前后胃泌素、胃电图的改变情况。结果治疗后两组胃电图、胃电节律明显好转,胃泌素明显下降,与治疗前比较差异均有显著性(P<001),但两组间比较差异无显著性。停药3个月两组均随访15例,中药组复发1例,西药组复发2例,余未见不良反应发生。结论凉润通络中药可以明显改善DGP患者的胃肠动力和胃肠激素的异常。

To explore the effect of Chinese herbs (CH) for cool moistening and freeing collaterals on gastro dynamic disturbance in patients of diabetes mellitus type 2 with gastroparesis (DM GP). MethodsFifty three patients of DM GP were enrolled and treated with CH (n=28) and Cisapride (n=25) respectively for 4 weeks, the changes of gastrin and electro gastrogram (EGG) before and after treatment were observed. ResultsAfter treatment, the EGG improved significantly, showing the rhythm significantly improved, and level of serum gastrin lowered significantly, as compared with those before treatment, the difference was significant (P< 0 01), but insignificant difference was found between the two groups. Fifteen patients in each group were followed up afar stopping medication for 3 months, recurrence occurred in 1 patient of CH treated group, and 2 patients of Cisapride treated group. No adverse reaction was found in the rest patients. ConclusionCH could obviously improve the gastro intestinal motility and hormones abnormality.