纳洛酮治疗非外伤性急性脊髓损伤的疗效观察

Clinical application of naloxone for acute non traumatic spinal cord injury.

目的探讨纳洛酮对急性非外伤性脊髓损伤的治疗作用。方法将40例急性非外伤性脊髓损伤患者随机分成2组,分别接受激素,激素加纳洛酮治疗,比较治疗前后神经缺失功能。结果治疗前两组神经功能评分无显著性差异,治疗14d、1个月后神经功能评分均有改善,观察组有效率为75%,显效率为50%;对照组有效率为65%,显效率为40%,两组比较有显著性差异。结论纳洛酮可作为治疗急性非特异性脊髓损伤的常规治疗方法。

Objective To investigate the effects of naloxone on acute non traumatic spinal cord injury.Methods 40 patients of acute non traumatic spinal cord injury were randomly divided into two groups,who were treated with hormone and naloxone.Neurological functional scores were compared.Result There was no significant difference in neurological functional scores between groups before treatment but the neurological functional scores were improved 14 days and 1 month after treatment.The efficacy was 75% and 65% in trail group and control group respectively,and the effective rates were 50% and 40%,respectively in trail group and control group,with significant difference.Conclusion Naloxone may be a routine treatment method for acute spinal cord injury.