Shy-Drager综合征7例临床分析及文献复习

Clinical analysis and literature review of seven cases with Shy-Drager syndrome.

目的探讨ShyDrager(SDS)综合征的临床特征及其早期诊断。方法回顾性分析7例SDS患者的临床资料。结果7例患者均有直立性低血压、排尿障碍,男性患者均以阳痿为首发症状,其他症状有共济失调、呛咳、喘鸣、帕金森样症状及锥体束征等。给予管通、维生素E、辅酶Q10治疗,症状改善不明显。结论SDS为神经变性性疾病,临床缺乏特异性检查方法,体位性低血压是其重要指标。目前尚缺乏有效治疗手段,预后也差。

Objective To investigate the clinical manifestation and early diagnosis of Shy Drager syndrome(SDS).Methods Clinical data of 7 SDS cases were retrospectively analyzed.Results All of 7 cases manifested orthostatic hypotension and disturbance of micturion.All male patients showed impotence as initial symptom.There were other symptoms such as ataxia,choking,wheezing,parkinsonism and pyramidal symptoms.These patients were not sensitive to midodrine,vitamin E and coenzyme Q 10 medication.Conclusion SDS is a chronic neurodegenerative disease without specific examination for early diagnosis except orthostatic hypotension.No effective therapeutic medication is available.Prognosis is poor.