海洛因依赖者左心构型及左心功能的超声心动图分析

ANALYSIS OF ECHOCARDIOGRAPHY IN VENTRICULUS SINISTER CORDIS CONFIGURATION AND FUNCTION IN HEROIN ADDICTS

目的 :观察海洛因依赖者的左心构型与左心功能变化 ,并进行左室充盈状态评价。方法 :应用超声心动图测量和分析 10 0例依赖者和 80例健康者的左心构型及左心功能。结果 :海洛因依赖者的左房径、室间隔厚度、左室后壁厚度大于健康组 (P <0 0 1) ,二尖瓣血流频谱E峰、A峰值减低 (P <0 0 5 ) ,肺静脉血流频谱S峰减低 ,D峰和AR峰值增高 (P <0 0 5 )。在不同滥用年限的海洛因依赖者中 ,吸毒年限在 0 5 - 1a者的左心构型及功能无明显变化 ;吸毒年限在 1- 5a者的左室后壁和室间隔增厚 ,D峰高于S峰 (P <0 0 5 ,P <0 0 1) ;吸毒年限在 5 - 10a者的左心构型及功能变化明显 (P <0 0 1)。结论 :海洛因依赖者的左心构型和功能改变明显 ;使用毒品时间越长 ,其左心构型及左室充盈。

Objective: To observe the changes of ventriculus sinister cordis configuration and function of heroin addicts. Methods: All indexes of ventriculus sinister cordis configuration And functionof 100 heroin addicts and 80 normal people in the same age group were measured and compared using echocardiography . Results: The LAD and LVPWT of heroin addicts were bigger than those of the normal group (P<0 01). Mitral flow patterns E peak and A peak decreased (P<0 05), E/A> pulmonary venous flow patterns S peak decreased , AR and D peak increased (P<0 05), S/D<1 , showing “ pseudo - normalized ” appearance . Heroin addicts who had used drugs less than one year had no obvious change in the ventriculus sinister cordis configuration and function ; those who had used drugs for 1-5 years indicated a more inflexible left ventricle (P<0 05); those who had used drugs had their left ventricle damaged showing abnormal contractive and diastolic function (P<0 01). Conclusion: Compared with normal people , heroin addicts left atrium dilated . Mitral flow patterns showed “pseudo -normalized ” appearance . The longer they use drugs , the greater the damage will be in their ventriculus sinister cordis configuration and function , contraction and diastolic of the left ventricle of heart .