腺样囊性癌的免疫组化研究

Adenoid cystic carcinoma: an immunohistochemical study

作者用三种单克隆抗体(癌胚抗原、S-100蛋白及细胞角蛋白8.12)对37例腺样囊性癌进行免疫组化研究。导管上皮形成的腺管样结构对三种抗体均呈阳性反应。部分肌上皮样细胞S-100蛋白及细胞角蛋白8.12阳性。癌胚抗原反应强度与患者预后有关。预后良好组癌胚抗原反应大多较强,而“预后不佳”组中,癌胚抗原反应弱者较多。S—100蛋白染色对于显示肿瘤侵犯神经,效果极佳。作者根据三种抗体染色的结果。讨论了腺样囊性癌的组织发生。

Immunohistochemical study was performed in 37 cases of adenoid cystic carcinoma with three kinds of monoclonal antibodies including anti—CEA, anti—S100 protein and anticytokeratin 8. 12. The tubular luminal material and ductal cells were positive for all three antibodies. Some myoepithelial cells were positive for S 100 perotein and CK 8. 12. The staining intensity of CEA was related to the patient's prognosis. Strong staining reaction was shown in the , most patients in'favorable' group. while weak staining reaction in 'unfavorable' group. Staing of S 100 protein could show the invasion of the tumor into the nerve very clearly. Depending on the immunohistochemical results of three antibodies, the histogenesis of adenoid cystic carcinoma was discussed.