涎腺恶性淋巴上皮病变的病理学研究

Pathological study on malignant lymphoepithelial lesions in the salivary gland

作者对3例涎腺恶性淋巴上皮病变进行了病理学研究。光镜下肿瘤由未分化的癌巢和淋巴组织间质构成,癌细胞含特征性的水泡状核和明显的嗜酸性核仁。网状纤维呈蜂窝状围绕癌巢。免疫组织化学研究证实,癌巢内含溶菌酶阳性的吞噬细胞,癌细胞内含细胞性角蛋白。表明本肿瘤是一种非神经内分泌性肿瘤,免疫反应参与其病理过程。

The malignant lymphoepithelial lesions in the salivary gland were pathologically studied under light and electronic microscopes in three patients. Under light microscope, the lymphoepithelial lesions consisted of undifferentiated carcinoma nest and lymphomesenchymal tissues; tumor cells comprised characteristic vesicular nucleus and clear eosinophilic nucleolus; and the carcinoma nest surrounded by reticulated fibers presented an alveolar structure. Immunohistochemically, the carcinoma nest comprised phagocytes positively reacted to lysozgyme and carcinoma cells reacted to cytokeratin. The present results indicated that this carcinoma was a nonendocrine tumor and an immune process may be involved in its pathophysiology.