摘要
目的探讨降糖舒心颗粒防治糖尿病合并冠心病机理及对主动脉低密度脂蛋白受体基因(LOX-1mRNA)表达的影响。方法采用链脲佐菌素(STZ)腹腔注射和高热量饲料喂养建立2型糖尿病并发动脉粥样硬化大鼠模型,应用Southern杂交法定量分析大鼠主动脉LOX-1mRNA的表达。结果给降糖舒心颗粒3个月后较其它用药组大鼠主动脉LOX-1mRNA增加明显,与模型对照组比较差异有显著性。结论降糖舒心颗粒抗糖尿病并发动脉粥样硬化的作用可能与其提高主动脉LOX-1mRNA的表达有关。
Objective:To observe the effect of JiangtangshuxinGranule(降糖舒心颗粒,JG)on LOX-1 gene expression of arota in diabetes with artherosclerosis(AS)model rat.Methods:The experimental model rats were yielded by ip streptozotocin(75mg/kg)and feeding hyperotrophic food.Then observed LOX-1 gene expression by Southern blotting.Results:After 3 months of JG treatment,the LOX-1 gene expression on rat arotic enhanced obviously,the comparison between the experimental group and the model controlled group showed significant difference.Conclusion:JG could increase LOX-1 mRNA gene expression.It may be caused the receptor augment,hence revealed its anti-atherosclerosis effect.
出处
《中国中医急症》
2004年第12期831-832,共2页
Journal of Emergency in Traditional Chinese Medicine
关键词
2型糖尿病
动脉粥样硬化
降糖舒心颗粒
氧化型低密度脂蛋白受体
基因表达
Type 2 diabetess,atherosclerosis,Jiangtangshuxin Granule(降糖舒心颗粒),oxidized low-density,lipoprotein receptor,gene expression
