静脉麻醉药与脑保护受体机制
Intravenous anesthetics and the receptor mechanism of neuroprotection
摘要
兴奋毒性可能是造成神经元死亡的“最后公路”。已知静脉麻醉药 ,如非竞争性NMDA受体拮抗剂 (氯胺酮 )和GABA受体模拟剂 (丙泊酚 )有神经保护作用 。
The excitotoxicity may be the last public way by which neurons were led to death. It has been shown that intravenous anesthetics, such as non-competitive NMDA antagonists (ketamine) or GABAmimetics (propofol) have neuroprotection. The receptor mechanism of neuroprotection by intravenous anesthesia was reviewed in this essay.
出处
《上海第二医科大学学报》
CSCD
2004年第11期978-980,共3页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
静脉麻醉药
脑保护
受体机制
兴奋性氨基酸
excitatory amino acid
NMDA
brain protection
intravenous anesthetics
参考文献19
-
1Shapiro HM,Galindo A,Wyte SR,et al.Rapid intraoperative reduction of intracranial pressure with thiopentone [J].BJA,1972,44:1 200-1 204.
-
2Jun G,Fanjie M,Guangyi Z,et al.Free radicals are involved in continuous activation of nonreceptor tyrosine protein kinase c-Src after ischemia/reperfusion in rat hippocampus [J].Neuroscience Letters,2003,345:101-104.
-
3Stafstrom CE,Sasaki-Adams DM.NMDA-induced seizures in developing rats cause long-term learning impairment and increased seizure susceptibility [J].Epilepsy Res.2003,53:129-137.
-
4Haeseler G,Tetzlaff D,Bufler J,et al.Blockade of voltage-operated neuronal and skeletal muscle sodium channels by S(+)-and R(-)-ketamine [J].Anesth Analg,2003,96:1 019-1 026.
-
5Smith DS,Keykhah MM,O'Neill JJ,et al.The effect of etomidate preteatment on cerebral high enery metabolites,lactate,and glucose during severe hypoxia in the rat [J].Anesthesiology,1989,71:438-443.
-
6Drummond JC,Cole DJ,Patel PM,et al.Focal cerebral ischemia during anesthesia with etomidate,isoflurane,or thiopental:A comparison of the extent of cerebral injury [J].Neurosurgery,1995,37:742-749.
-
7Ravussin P,de Tribolet N.Total intravenous anesthesia with propofol for burst suppression in cerebral aneurysm surgery:Preliminary report of 42 patients [J].Neurosurgery,1993,32:236-240.
-
8Amorim P,Chambers G,Cottrell J,et al.Propofol reduces neuronal transmission damage and attenuates the changes in calcium,potassium,and sodium during hyperthermic anoxia in the rat hippocampal slice [J].Anesthesiology,1995,83:1 254-1 265.
-
9Nakao S,Nagata A,Miyamoto E,et al.Inhibitory effect of propofol on ketamine-induced c-Fos expression in the rat posterior cingulated and retrosplenial cortices is mediated by GABAA receptor activation [J].Acta Anaesthesiol Scand,2003,47:284-290
-
10Lingamaneni R,Hemmings HC.Differential interaction of anaesthetics and antiepileptic drugs with neuronal Na+ channels,Ca2+ Channels,and GABAA receptors [J].BJA,2003,90:199-211.
-
1赵东宝.糖皮质激素治疗肾小球疾病的受体机制[J].医学综述,1995,1(7):301-302.
-
2徐仁宝.休克时糖皮质激素受体的变化及大剂量糖皮质激素抗休克治疗的受体机制[J].基础医学与临床,1998,18(1):5-10. 被引量：48
-
3徐仁宝.大剂量激素作用的受体机制以及危重病人激素治疗的新策略[J].外科理论与实践,2000,5(2):76-78. 被引量：13
-
4焦悦,郭建友,李守业,朱妍,李昌煜.神经病理性疼痛的受体机制研究进展[J].中国药理学通报,2012,28(5):593-597. 被引量：7
-
5于明琨.兴奋性氨基酸与脑损伤的非受体机制[J].解放军医学情报,1995,9(1):27-29.
-
6陈秉学.α_2肾上腺素能受体机制与麻醉[J].国外医学（麻醉学与复苏分册）,1991,12(2):86-88.
-
7王莉,杭燕南,金正均.静脉麻醉药与脑保护受体机制[J].中国麻醉与镇痛,2004,6(1):66-68.
-
8李明,杨晔,刘植珊,吴岳嵩,孙庆斌,叶晓健,洪新如,顾雄华.强啡肽A在脊髓继发性损伤中阿片样及非阿片样受体机制的实验研究[J].中华骨科杂志,1996,16(2):109-113. 被引量：2
-
9李启忠,王向阳.爱普列特减少经尿道前列腺汽化电切术中出血的作用研究[J].河南医学研究,2006,15(4):336-338. 被引量：6
-
10左萍萍.缺血性脑损伤与谷氨酸兴奋毒性[J].基础医学与临床,1994,14(1):9-11. 被引量：2
