艾滋病合并结核病近期临床疗效观察

Diagnosis and short-term therapeutic effect of AIDS complicated by tuberculosis

目的探讨艾滋病合并结核病的诊断及治疗的近期疗效。方法对河南省某局部地区98例艾滋病合并结核病患者的临床资料进行分析。结果98例艾滋病合并结核病患者以发热、咳嗽、盗汗、体质量降低、浅表淋巴结肿大、呼吸困难为常见症状。采用鸡尾酒疗法抗病毒治疗以及6个月短程方案2SHRZ/4HRZ抗结核治疗[S (链霉素) 、H (异烟肼)、R( 利福平) 、Z( 吡嗪酰胺)],病人临床症状、体征、病灶吸收率、空洞好转率、免疫功能均有改善。结论结核科医师应加强对HIV合并结核诊断的认识。痰涂片检查抗酸杆菌及X线检查仍具有较好的诊断价值,结核病诊断及结核菌素试验阴性不能排除结核,短期抗结核治疗具有一定效果。

Objective To investigate the shore-term therapeutic effects of AIDS complicated by tuberculosis. Methods Ninety-eight AIDS patients with tuberculosis living in a village in Henan province were observed. Results Among the 98 patients, fever, cough, night sweating, weight loss, and superficial lymph node swelling were the common symptoms. Highly active anti-retroviral therapy (HAART) combined with a 6-month anti-tuberculosis treatment protocol with streptomycin, isoniazid, rifampin, and pyrazinamide (2SHRZ/4HRZ) resulted in improvement of the patients' clinical symptoms and signs as well as the immune functions. Conclusion AIDS complicated by tuberculosis should receive due medical attention and sputum smear examination for anti-acid bacillus combined with X-ray examination possesses good diagnostic value for tuberculosis in these patients, for whom short-tern anti-tuberculosis treatment may have beneficial effects.