米非司酮治疗绝经前期子宫肌瘤疗效观察

MIFEPRISTONE TREATMENT OF UTERINE LEIOMYOMA IN PERIMENOPAUSAL PATIENTS

目的观察米非司酮对绝经前期子宫肌瘤的治疗效果。方法米非司酮 12 .5mg 1次 /d口服治疗绝经前期子宫肌瘤 2 0例 3个月 ,治疗前和 3个月后分别用彩色超声波测量子宫及肌瘤体积 ;同法取同期绝经前期子宫肌瘤 18例为对照组期待观察 3个月。结果治疗组 3个月后子宫及肌瘤体积均缩小 (P <0 .0 1) ,而对照组各指标无明显变化 (P >0 .0 5 )。结论米非司酮对绝经前期子宫肌瘤有效 。

ObjectiveTo study the responese of uterine leiomyoma in perimenopause patients to mifepristone. MethodsTwenty perimenopausal patients with uterine leiomyoma were treated with 12.5 mg of mifepristone daily for 3 months as mifepristone group,18 perimenopausal patients with uterine leiomyoma without mifepristone treatment were observed for 3 months as control group. ResultsAfter 3 months of mifepristone treatment,the uterine and leiomyoma were significantly decreased in size in mifepristone group(P< 0.01),while no significant changes were observed in control group(P> 0.05). ConclusionMifepristone is effective in the treatment of perimenopausal patients with uterine leiomyoma and it is a nice remedial method.