通列舒胶囊对大鼠非细菌性前列腺炎模型的影响

Therapeutic Effect of Tonglieshu capsules for Nonbacterial Prostatitis

[目的]观察通列舒胶囊(由乌药、荔枝核、王不留行、延胡索、三棱、莪术、蒲公英、板蓝根、槐花、黄精、瞿麦等组成)对非细菌性前列腺炎的治疗作用。[方法]SD大鼠40只,随机分为4组,分别为正常对照组、模型组、通列舒组和前列通组;除正常对照组外,其他组均采用大鼠前列腺体内直接注射消痔灵法复制非细菌性前列腺炎病理模型;通列舒组胃饲通列舒1.25g/kg,前列通组胃饲前列通7.5g/kg,正常对照组及模型组灌胃生理盐水2mL,连续4周,观察各组前列腺组织中白细胞数和卵磷脂小体密度及间质或腺腔内炎细胞浸润的例数。[结果]通列舒组的前列腺组织中白细胞密度降低,卵磷脂小体密度升高,与模型组比较有显著性差异(P<0.01),且作用优于前列通组(P<0.05);前列腺组织内炎细胞浸润明显减少,但尚未达正常水平,通列舒与前列通作用无显著性差异(P>0.05)。[结论]通列舒胶囊能够降低前列腺组织白细胞数.减轻炎细胞浸润,增加卵磷脂小体数,对慢性前列腺炎具有一定的治疗作用。

[ Objective ] To investigate the therapeutic effect of Tonglieshu capsules (mainly composed of Radix Linderae, Semen Litchi, Semen Vaccariae, Rhizoma Corydalis, Rhizoma Sparganii, Rhizoma Curcumae, Herba Taraxaci, etc. ) for nonbacterial prostatitis. [Methods] Forty SD rats were randomized to 4 groups: normal control group (group A) , model group (group B), Qianlietong group (group C) and Tonglieshu, Capsules (group D). Except those in group A, rats in other groups were injected with Xiaozhiling Injection directly into the prostatic glands to establish nonbacterial prostatitis. After treatment with Tonglieshu capsules for 4 weeks, white blood cells counting, density of lecithin corpuscle and inflammatory cells infiltrating into interstitium and glandular lumen of prostatic tissues were observed. [Results] WBC counting was decreased and density of lecithin corpuscle increased in group D (P <0.01 compared with model group) and the effects were better than those in group C ( P < 0.05) ; prostatic inflammatory cells infiltration was obviously decreased in group D but still higher than the normal level and did not differ from that in group C (P >0.05) . [Conclusion] Tonglieshu capsules has an effect in treating chronic prostatitis by decreasing the WBC counting, reducing infiltration of inflammatory cells and increasing the density of lecithin corpuscle in prostatic tissues.