多巴胺合并酚妥拉明治疗病毒性肝炎难治性黄疸的疗效

Efficacy of dopamine co-administrated with phentolamine in the treatment of refractory icteric viral hepatitis

目的:探讨多巴胺合并酚妥拉明治疗病毒性肝炎难治性黄疸的疗效。方法:病毒性肝炎伴顽固性黄疸患者共60例,分为治疗组和对照组各30例,对照组采用综合治疗,治疗组为综合治疗无效的病例,应用酚妥拉明10-20mg合并多巴胺20-40mg,静滴,qd,辅以输注白蛋白、血浆,疗程为30d。结果:治疗组在降低转氨酶、消退黄疸方面的疗效与治疗前比较差异有显著性(P<0.05),总有效率为73.3％,明显优干对照组的53.3％(P<0.05),且无严重不良反应。结论:酚妥拉明与多巴胺合用治疗难治性黄疸,疗效较好,不良反应小,值得临床推广。

Objective: To assess whether the co-administration of dopamine and phentolamine would be effective in the treatment of refractory icteric viral hepatitis. Methods:60 patients with refractory icteric virus hepatitis were equally assigned to either control arm or treatment arm. The patients in the control arm received complex treatments,and those in the treatment arm,who had not responded to the complex treatments, were intravenously given daily with dopamine co-administrated with phentolamine plus the plasma albumin infusion for 30 days. Results:The study showed that treatment arm yielded a significant, 73. 3 % , overall response rate in decreasing transaminase level and improving jaundice compared with 53.3 % of the control arm (P<0.05). No serious adverse events were reported. Conclusion: A more effective and safe treatment of refractory icteric viral hepatitis was attained by giving patients with co-administration of dopamine and phentolamine.