低氧血症与SARS肝损伤的关系及还原型谷胱甘肽对肝损伤的疗效

The relationship between hypoxemia and SARS complicated liver injury and the efficacy of reduced glutathione in treatment of the disease

目的:观察低氧血症与严重急性呼吸综合征(SARS)的关系及还原型谷胱甘肽(TAD)对SARS肝损伤的疗效。方法:对37例SARS并肝损伤患者予以TAD 600mg加入5％葡萄糖溶液250mL中静脉滴入,qd,2周为1个疗程;同时测定治疗患者的血氧分压,观察治疗前后肝功能(ALT,AST,TBil和GGT)变化及不良反应。结果:治疗前后肝功能(ALT,AST和GGT)差异有显著性(P<0.01),总有效率81.1％,无不良反应发生;低氧血症组ALT和AST明显高于血氧正常组,差异具有显著性;而TBil两组差异无显著性。结论:低氧血症与肝功能异常关系密切。TAD在治疗SARS肝脏损伤方面疗效显著且无不良反应。

Objective:To observe the efficacy of reduced glutathione (TAD) on SARS complicated liver injury. Methods: 37 patients with SARS complicated liver injury were treated with TAD 600mg once daily given by infusion after dissolved in 5% glucose injection for 2 weeks and their hepatic functions (ALT,AST,GGT) were determined before and after treatment. Results:The hepatic functions were significantly improved after treatment and the effective rate of reduced glutathione in this study was 81.1% ,no adverse drug reactions were observed.Conclusion:TAD show satisfactory therapeutic effect in treatment of SARS complicated liver injury.