黄芩清肺分散片中黄芩苷的体外溶出度研究

In vitro dissolution rate of baicalin in huangqin qingfei dispersible tablets

目的 探讨黄芩清肺分散片中黄芩苷的体外溶出度及溶出动力学。方法 采用浆法,以自制普通片为参比制剂,采用HPLC法测定了两制剂在pH分别为1.0、2.8、4.5、6.8四种不同溶出介质中黄芩苷的累积溶出度,并分别用零级释放模型、单指数模型、对数正态分布模型及威布尔分布函数进行溶出动力学模拟。结果 分散片中黄芩苷的溶出受pH值影响较大,在pH为4.5时溶出较完全,溶出过程以威布尔分布模型拟合最佳,与普通片比较,溶出速率快,溶出更完全。结论 黄芩清肺分散片中黄芩苷在pH为4.5时体外溶出动力学符合威布尔分布模型,分散片具有速释作用。

OBJECTIVE To determine the in vitro dissolution rate of baicalin in huangqin qingfei dispersible tablets. METHODS A reversed-phase HPLC method was developed to determine the in vitro dissolution rate of baicalin. We compared huangqin qingfei dispersible tablets with the conventional tablets in the dissolution medium when the pH values were 1.0, 2.8, 4.5, and 6. 8 by paddle method Zero-class model, single-index model, logarithm normal school model, and Weibull distributing model were used to imitate the dissolution curve. RESULTS The dissolution rate of baicalin dispersible tablets was affected greatly by the pH and dissolved completely when the pH was 4. 5. The dissolution rate in vitro imitatation in Weibull distributing model was the best Compared with the conventional tablets, the dispersible tablets dissolved quickly and completely. CONCLUSIONS The in vitro dissolution rate of baicalin in huangqin qingfei dispersible tablets conforms to Weibull distributing model when the pH of the dissolution medium is 4. 5. Dispersible tablets may release rapidly.