妇宝颗粒的主要药效学研究

Pharmacodynamics studies of Fubao granules

目的 评价妇宝颗粒的主要药效 ,为临床疗效提供实验依据。方法 抗炎试验、免疫试验、镇痛试验、出凝血试验。结果 妇宝口服灌胃给药 3d能显著抑制蛋清所致大鼠足肿胀、抑制醋酸所致小鼠腹腔毛细血管通透性增加和二甲苯所致的小鼠耳肿胀 (P <0 .0 1) ,对醋酸所致小鼠的扭体数也有较好的抑制作用 (P <0 .0 1) ,说明有一定的镇痛作用 ,连续灌胃 10d ,小鼠脾重明显增加 (P <0 .0 1) ,但对小鼠胸腺没有明显影响 ,能明显增加 2 ,4 二硝基氯苯所致的小鼠耳肿胀 (P <0 .0 1) ,说明妇宝对2 ,4 二硝基氯苯所致迟发型超敏反应有一定的增强作用 ;能明显增加小鼠吞噬系数 (P <0 .0 1或P <0 .0 5 ) ,说明妇宝能增强小鼠对血流中惰性炭粒的吞噬廓清能力 ;妇宝连续口服灌胃 3d ,能明显减少小鼠出凝血时间 (P <0 .0 5 )。结论 妇宝颗粒具有抗炎、镇痛、提高免疫力和缩短出、凝血时间的作用。

OBJECTIVE To give some valuable data for the evaluation on the clinical effects of Fubao granules. METHOD The methods of this study included anti-inflammatory experiment ,immune response test ,relieve pain test ,natural bleeding and blood coagulation test. RESULTS 1.Fubao granules could significantly inhibit the foot swelling induced by egg white in rat, meanwhile, it could significantly inhibit the increase of penetrability of abdominal capillary vessel induced by acetic acid and ear swelling induced by xylene and reduced the number of writhing induced by acetic acid in mice; 2. Fubao granules could profoundly raise spleen index but couldn’t raise thymus index in mice .3.Fubao granules could significantly increase ear swelling induced by 2,4-dinitrochlorobenzol and increase Carbon Clearance index and phagocytose index in mice. 4.Fubao granules could prolong the time of capillary blood coagulation and showed an obvious effect on the time of bleeding in mice.