两种阿奇霉素制剂对下呼吸道感染的疗效比较

Evaluation of the Efficacy and Safety of Two Kinds of Injectable Azithromycin Preparations in Treatment of Lower Respiratory Tract Infection

目的 :评价注射用枸橼酸阿奇霉素 (商品名 :圣诺灵 )治疗下呼吸道细菌感染的临床疗效及其安全性。方法 :采用随机对照研究方法 ,将 12 0例病人随机分成试验组和对照组 ,各 6 0例。试验组使用注射用枸橼酸阿奇霉素 5 0 0g ,静滴 ,qd ,疗程 5天 ;对照组使用注射用乳糖酸阿奇霉素 5 0 0g ,与试验组同法给药。比较两种阿奇霉素制剂治疗下呼吸道感染的临床疗效、细菌学评价及不良反应。结果 :试验组的痊愈率和总有效率分别为 35 0 %和10 0 % ,细菌清除率为 96 5 % ,不良反应发生率为 5 0 % ;对照组的痊愈率和总有效率分别为 30 .0 %和 96 7% ,细菌清除率为 94 7% ,不良反应发生率为 11 7%。结论 :注射用枸橼酸阿奇霉素的临床疗效、细菌清除率与注射用乳糖酸阿奇霉素相当 ,不良反应发生率则相对较低。

Objective: To evaluate the efficacy and safety of two kinds of injectable azithromycin in treatm-ent of lower respiratory tract infections. Methods: 120 patients were divided randomly into trial group and co-ntrol group of 60 patients each,azithromycin citrate given in trial group and its lactobionate given in control group. A regimen of 500 mg/d,iv gtt,for 5～7 days was used for both groups. Results: The cure rate,eff-ective rate,bacterial clearance rate and side-effect incidence rate were 35.0%,100.0%,96.5% and 5.0% respectively for trail group and were 30.0%,96.7%,94.7% and 11.7% respectively for control group. Co-nclusion: Injectable azithromycin citrate is a safe and effective agent for treatment of lower respiratory tract in-fection.