Ⅱ型肾病综合征血脂、脂蛋白变化及其相关因素研究

Study of Lipids Lipoproteins and Associated Factors in TYPE II Nephrotic Syndrome

本文观察15例Ⅱ型肾病综合征血脂、脂蛋白,与20例正常人比较。结果病人TC、TG、LDL-C显著增高,HDL_2-C显著降低,同时发现病人RC,TG,LDL-C与血白蛋白呈显著负相关,血脂、脂蛋白与血肌酐呈轻度正相关。提示Ⅱ型肾病综合征存在广泛脂质及脂蛋白异常,是并发心血管疾病及肾脏病恶化的危险因素。

The serum lipids and lipoproteins in 15 type Ⅱ nephrotic syndrome were studied and compared with 20 health controls. The serum TC, TG, LDL-C were significantly increased. There were the inverse correlation between serum TC, TG, LDL-C and albumin and the week positive corre ation between serum lipids, lipoproteins and creatinine. These suggested that there be the wide abnormalities of lipids and lipoproteins in type Ⅱ nephrotic syndrome which may be risk factors of cardiovascular disease and progressive renal diseases.