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救心胶囊对缺氧损伤内皮细胞黏附分子表达的影响 被引量：2

The influence of Jiuxin capsule on the expression of adhesion molecule from injured endothelium cell by hypoxia
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摘要 犤目的犦以内皮细胞(EC)为研究对象,观察救心胶囊对缺氧损伤内皮细胞黏附分子释放的影响。犤方法犦运用免疫细胞化学技术,通过进行内皮细胞培养,观察内皮细胞缺氧损伤后,黏附分子(VCAM-1、ICAM-1)在细胞浆的表达情况。犤结果犦缺氧损伤使VCAM-1、ICAM-1表达显著升高。救心胶囊组,VCAM-1、ICAM-1表达显著降低。犤结论犦救心胶囊能显著降低黏附分子表达,保护内皮细胞免受炎症介质损伤。 Objective The mechanism of Jiuxin capsule on coronary heart disease (CHD)through observing the influence of Jiuxin capsule on the expression of adhesion molecule from injured endothelium cell by hypoxia.Methods Through cultivating endothelium cell in vitro,the expression of adhesion molecule (VCAM-1,ICAM-1)in cytoplasm was observed by immunochemistry in hypoxia injured endothelium cell.Result The expression of adhesion molecule increased markedly after endothelium cell was injured by hypoxia,and Jiuxin capsule coul inhibit .Conclusion Jiuxin capsule can markedly decrease the expression of adhesion molecule of endothelium cell,and protect the endothelium cell against injured by inflammation mediater.
作者 李春深 陈静 范英昌
机构地区 天津中医学院
出处 《天津中医学院学报》 2004年第3期129-131,共3页 Journal of Tianjin College of Traditional Chinese Medicine
基金 天津市卫生局课题(02042)
关键词 救心胶囊 缺氧损伤 内皮细胞 黏附分子 中药 Jiuxin capsule adhesion molecule endothelium cell hypoxia
分类号 R286.2 [医药卫生—中药学]
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天津中医学院学报
2004年 第3期

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