应用OKT单克隆抗体对慢性萎缩性胃炎及胃癌患者免疫状态测定研究

Study of Immunologic State on Patients with Chronic Atrophic Gastritis and with Gastric Carcinoma by OKT Monoclonal Antibodies

本文用OKT单抗,采用间接SPA菌花环法对36例慢性萎缩性胃炎(CAG)患者、16例术前胃癌患者、10例术后胃癌患者进行T亚群检测。实验结果:CAG患者的OKT_3花环形成率未见明显改变;OKT_4花环形成率降低;OKT_3花环形成率升高;T_4/T_8比值下降,T亚群处于失调状态。术前胃癌患者的OKT_3花环形成率及T_4/T_8比值既低于正常人,也低于CAG患者,表明胃癌患者的T亚群失调甚于CAG患者。但胃癌术后2～3周,上述指标全部恢复正常。

The T lymphocyte subsets were tested on 36 patients with CAG, 16 patients with preoperation gastric carcinoma and 10 patients with postoperation gastric carcinoma by using OKT McAb and indirect method of SPA bacterial rosets. The results are: there is no obvious change on the forming rate of OKT_3 rosets on CAG patients; the forming rate of OKT_4 rosets are reduced; the forming rate of OKT_8 rosets is increased, and the specific value of T_4/T_8 is reduced. This indicates that although the total number of T cells on CAG patients is normal, the T lymphoyte subsets are in a disorder condition. The forming rate of OKT_3 bacterial rosets on patients with preoperation gastric carcionma and the sepcific value of T_4/T_8 are lower than normal people. This indicates that the disorder of T lymphocyte subsets on patients with gastric carcinoma is much more serious than that on CAG patients, But 2～3 weeks after the operation, all the above indexes are back to normal, It is also found that the index of T_4/T_8 on serious CAG patients is lower than that on light and middle degree patients. This indicates that the disorder of T lymphocyte subsets on former is more serious than the latter.