老年高血压病患者血浆5-羟色胺等物质的变化及其意义

Studies on plasma 5-HT of other Related Substances in Elderly Essential Hypertension

对40例老年高血压病(EH)患者、26例中年EH患者、50例健康人的血浆中5-羟色胺(5-HT)、5-羟吲哚乙酸(5-HIAA)、去甲肾上腺素(NE)含量的观察结果发现,老年和中年EH患者5-HT、5-HIAA、NE值均明显高于健康组,老年组5-HT又高于中年组,老年和中年EH患者5-HT与平均动脉压均呈正相关性。5-HT的升高与NE的下降呈负相关性。老年舒张期EH者比单纯收缩期EH者5-HT值升高明显,EH并发冠心病时5-HT增高尤为显著。

40 cases of elderly essential hypertension (EH), 26 cases of middle aged EH and 50 healthy subjects werestudied,with changes in plasma 5-HT (5-Hydroxytryptamine), 5-HIAA, (5-Hydroxy-indoleacetie aeid) andNE (Norepinephrine) examined by modified shellenberger method. The mean values of plasma 5-HT (2.22±0. 59,1. 67±0. 54) and NE (1. 12±0. 40,1. 47±0.35) were signifcantly higher in both elderly EH and middleaged EH than that were in healthy subjects (5-HT mean values 0.68±0.20,NE mean values 0.82±0.41) P<0.01. Correlation of mean aterial pressure to 5-HT in elderly EH (r=0.786,P<0.01) and in middle age EH(r=0. 694 ,P<0. 01) ,but there was nepative relations between 5-HT and NE in both groups of patients (r=-0. 592,P<0.01, r=-0. 480,P<0. 05). The plasma level of 5-HT was prominenetly higher in elderly EH, especially in those with diastolic hyper-tension or complicated with coronary heart disease.