老年性痴呆早期诊断的“评定系数”测示研究

Research on the Early Diagnosis of the Aged Patients with Dementia

当前社会人口已趋向老龄化,老年病发生率日渐增多。老年性痴呆无论对家庭或社会危害均大,其发病率在美国约占65岁以上老年人口的8.9％～10.6％,病因多为Alzheimer氏病形式;日本的发病率为7.2％～8.6％,多为血管性痴呆的表现形式。

Our epidemiological survey was carried out in an urben arer in Wuhan. The inciduce rate of the agedpatients with dementia was 6.2%. 90 patients were determined by clinical symptoms and head CT and MRI,ofwhich 65 cases were MID (72.22%), 7 cases were Binswanger's disease (7.77%) and the remain wereAlzheimer's disease or Prakinson's disease eomplicatecd with. Through 25 checklist item screening and multi-correlation analysis, we found that the solid intelligenceis was more important than the fluid intelligence in diag-nosing aged patients with dementia, because the solid intelligence are obviorsly decreased especially in agedpatients with dementia and the decrease of the fluid intelligence is common in the aging. We also studied the treatment by Hydergin of these patients. 78 of 90 were as treatment group,and another 12 patients control group. The 30 healthy aged were as correct guoup. The results were computerized andan equation was presented as follows: x=(x_1+_(2+)+x_3+x_4+x_5+x_6)×0. 8+ (x_7+x_8)×1.6/100 According to our results, it is suggested that x may be as an early diagnostical criteria for aged patientswith dementia. Our results showed that if x>0.24, the aged may be normal, if x was between 0. 2～0.24, thepatient was suspecious, needing to examine by head CT and MRI to determine whether there were multipleinfarctions or not and if x<0. 12, the patient may be diagnosed as senile dementia and the treatment efficency ofHydergin was poor