莪术对肾间质病变引起的早期慢性肾功能衰竭影响的临床观察

Clinical Effects of Curcuma Phaeocaulis Valeton on Early-Stage Chronic Rena l Failure

观察莪术在临床上治疗因肾脏间质病变引起的早期慢性肾功能不全的疗效机理 ,将 4 5例肾功能不全患者 (Scr<35 0 μmol/L)随机分为治疗组 (补肾健脾方 +莪术 )和对照组 (补肾健脾方 ) ,服药 3个月。结果 :治疗组内皮素、TXB2 、PGF1α、PGF1α/TXB2 、肾B超基质定量治疗前后比较有显著性差异。提示莪术可以通过调节内皮素及血栓素 前列腺素系统平衡来延缓早期慢性肾功能衰竭进程。

To explore the mechanism of Curcuma Phaeocaulis Valeton in the treatment of early-stage chronic renal failure, 45 subjects were randomize d into two groups: treatment group in which 25 cases were treated by “Bushen Ji anpi Decoction” plus Curcuma Phaeocaulis Valeton and control group in which 20 cases were treated by “Bushen Jianpi Decoction”, with a course of three mo nths. Results: There were significant differences in ET-1, TXB 2, PGF 1 α, PGF 1α/TXB 2 and renal cortex ration between pretreatment and p osttreatment in treatment group. It is revealed that Curcuma Phaeocaulis Valet on can regulate endothelium system and PGF 1α/TXB 2 balance to dela y the progression of early-stage chronic renal failure.